Group publications

 

Publikationer rss feed

2018
 

Metabolite ratios as potential biomarkers for type 2 diabetes: a DIRECT study

Molnos, Sophie ; Wahl, Simone ; Haid, Mark ; Eekhoff, E. Marelise W. ; Pool, René ; Floegel, Anna ; Deelen, Joris ; Much, Daniela ; Prehn, Cornelia ; Breier, Michaela ; Draisma, Harmen H. ; van Leeuwen, Nienke ; Simonis-Bik, Annemarie M.C. ; Jonsson, Anna Elisabet ; Willemsen, Gonneke ; Bernigau, Wolfgang ; Wang-Sattler, Rui ; Suhre, Karsten ; Peters, Annette ; Thorand, Barbara ; Herder, Christian ; Rathmann, Wolfgang ; Roden, Michael ; Gieger, Christian ; Kramer, Mark H.H. ; van Heemst, Diana ; Pedersen, Helle Krogh ; Gudmundsdottir, Valborg ; Schulze, Matthias B. ; Pischon, Tobias ; de Geus, Eco J.C. ; Boeing, Heiner ; Boomsma, Dorret I. ; Ziegler, Anette G. ; Slagboom, P. Eline ; Hummel, Sandra ; Beekman, Marian ; Grallert, Harald ; Brunak, Søren ; McCarthy, Mark I. ; Gupta, Ramneek ; Pearson, Ewan R. ; Adamski, Jerzy ; 'T Hart, Leen M.
in journal: Diabetologia (ISSN: 0012-186X) (DOI: http://dx.doi.org/10.1007/s00125-017-4436-7), vol: 61, pages: 117-129, 2018

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: http://dx.doi.org/10.1007/s00125-017-4436-7

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miRandola 2017: a curated knowledge base of non-invasive biomarkers

Russo, Francesco ; Di Bella, Sebastiano ; Vannini, Federica ; Berti, Gabriele ; Scoyni, Flavia ; Cook, Helen Victoria ; Santos, Alberto ; Nigita, Giovanni ; Bonnici, Vincenzo ; Laganà, Alessandro ; Geraci, Filippo ; Pulvirenti, Alfredo ; Giugno, Rosalba ; De Masi, Federico ; Belling, Kirstine González-Izarzugaza ; Jensen, Lars Juhl ; Brunak, Søren ; Pellegrini, Marco ; Ferro, Alfredo
in journal: Nucleic Acids Research (ISSN: 0305-1048) (DOI: http://dx.doi.org/10.1093/nar/gkx854), vol: 46, issue: D1, pages: D354-D359, 2018

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: http://dx.doi.org/10.1093/nar/gkx854

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Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study

Gudmundsdottir, Valborg ; Pedersen, Helle Krogh ; Allebrandt, Karla Viviani ; Brorsson, Caroline Anna ; van Leeuwen, Nienke ; Banasik, Karina ; Mahajan, Anubha ; Groves, Christopher J ; van de Bunt, Martijn ; Dawed, Adem Y ; Fritsche, Andreas ; Staiger, Harald ; Simonis-Bik, Annemarie M C ; Deelen, Joris ; Kramer, Mark H H ; Dietrich, Axel ; Hübschle, Thomas ; Willemsen, Gonneke ; Häring, Hans-Ulrich ; de Geus, Eco J C ; Boomsma, Dorret I ; Eekhoff, Elisabeth M W ; Ferrer, Jorge ; McCarthy, Mark I ; Pearson, Ewan R ; Gupta, Ramneek ; Brunak, Søren ; 't Hart, Leen M
in journal: P L o S One (ISSN: 1932-6203) (DOI: http://dx.doi.org/10.1371/journal.pone.0189886), vol: 13, issue: 1, 2018

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2018     |    DOI: http://dx.doi.org/10.1371/journal.pone.0189886

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Ibuprofen alters human testicular physiology to produce a state of compensated hypogonadism

Kristensen, David Møbjerg ; Desdoits-Lethimonier, Christèle ; Mackey, Abigail L ; Dalgaard, Marlene Danner ; De Masi, Federico ; Munkbøl, Cecilie Hurup ; Styrishave, Bjarne ; Antignac, Jean-Philippe ; Le Bizec, Bruno ; Platel, Christian ; Hay-Schmidt, Anders ; Jensen, Tina Kold ; Lesné, Laurianne ; Mazaud-Guittot, Séverine ; Kristiansen, Karsten ; Brunak, Søren ; Kjær, Michael ; Juul, Anders Christian ; Jégou, Bernard
in journal: Proceedings of the National Academy of Sciences of the United States of America (ISSN: 0027-8424) (DOI: http://dx.doi.org/10.1073/pnas.1715035115), 2018

Type: Journal article (Peer reviewed)

Status: Accepted/In press     |    Year: 2018     |    DOI: http://dx.doi.org/10.1073/pnas.1715035115

2017
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USP2 as a potential link between miR-125b and psoriasis

Wei, T. ; Folkersen, Lasse Westergaard ; Biskup, E. ; Xu, N. ; Manfe, V. ; Niazi, O. ; Gniadecki, R.
in journal: British Journal of Dermatology (ISSN: 0007-0963) (DOI: http://dx.doi.org/10.1111/bjd.14916), vol: 176, issue: 3, pages: 723-731, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1111/bjd.14916

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Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci

Jones, Gregory T ; Tromp, Gerard ; Kuivaniemi, Helena ; Gretarsdottir, Solveig ; Baas, Annette F ; Giusti, Betti ; Strauss, Ewa ; van 't Hof, Femke N ; Webb, Thomas ; Erdman, Robert ; Lindholt, Jes S. ; Folkersen, Lasse Westergaard
in journal: Circulation Research (ISSN: 0009-7330) (DOI: http://dx.doi.org/10.1161/CIRCRESAHA.116.308765), vol: 120, pages: 341-353, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1161/CIRCRESAHA.116.308765

 

Combinatorial Drug Screening Identifies Ewing Sarcoma-specific Sensitivities

Radic-Sarikas, Branka ; Tsafou, Kalliopi P ; Emdal, Kristina B. ; Papamarkou, Theodore ; Huber, Kilian V. M. ; Mutz, Cornelia ; Toretsky, Jeffrey A ; Bennett, Keiryn L. ; Olsen, Jesper V. ; Brunak, Søren ; Kovar, Heinrich ; Superti-Furga, Giulio
in journal: Molecular Cancer Therapeutics (ISSN: 1535-7163) (DOI: http://dx.doi.org/10.1158/1535-7163.MCT-16-0235), vol: 16, issue: 1, pages: 88-101, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1158/1535-7163.MCT-16-0235

 

Early differences in islets from prediabetic NOD mice: combined microarray and proteomic analysis

Crèvecoeur, Inne ; Gudmundsdottir, Valborg ; Vig, Saurabh ; Marques Câmara Sodré, Fernanda ; D'Hertog, Wannes ; Fierro, Ana Carolina ; Van Lommel, Leentje ; Gysemans, Conny ; Marchal, Kathleen ; Waelkens, Etienne ; Schuit, Frans ; Brunak, Søren ; Overbergh, Lut ; Mathieu, Chantal
in journal: Diabetologia (ISSN: 0012-186X) (DOI: http://dx.doi.org/10.1007/s00125-016-4191-1), vol: 60, issue: 3, pages: 475-489, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1007/s00125-016-4191-1

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Cutavirus in Cutaneous Malignant Melanoma

Mollerup, Sarah ; Fridholm, Helena ; Vinner, Lasse ; Kjartansdóttir, Kristín Rós ; Friis-Nielsen, Jens ; Asplund, Maria ; Herrera, Jose Romero ; Steiniche, Torben ; Mourier, Tobias ; Brunak, Søren ; Willerslev, Eske ; Gonzalez-Izarzugaza, Jose Maria ; Hansen, Anders Johannes ; Nielsen, Lars Peter
in journal: Emerging Infectious Diseases (ISSN: 1080-6040) (DOI: http://dx.doi.org/10.3201/eid2302.161564), vol: 23, issue: 2, pages: 363-365, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.3201/eid2302.161564

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EBI3 regulates the NK cell response to mouse cytomegalovirus infection

Jensen, Helle ; Chen, Shih-Yu ; Folkersen, Lasse Westergaard ; Nolan, Garry P ; Lanier, Lewis L
in journal: Proceedings of the National Academy of Sciences of the United States of America (ISSN: 0027-8424) (DOI: http://dx.doi.org/10.1073/pnas.1700231114), vol: 114, issue: 7, pages: 1625-1630, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1073/pnas.1700231114

 

Nomenclature for alleles of the human carboxylesterase 1 gene

Rasmussen, Henrik B. ; Madsen, Majbritt B. ; Bjerre, Ditte ; Ferrero, Laura ; Linnet, Kristian ; Thomsen, Ragnar ; Jorgens, Gesche ; Dalhoff, Kim ; Stage, Claus ; Stefansson, Hreinn ; Hankemeier, Thomas ; Kaddurah-Daouk, Rima ; Brunak, Søren ; Taboureau, Olivier ; Nzabonimpa, Grace Shema ; Jeppesen, Pia ; Kaalund-Jørgensen, Kristine ; Kristensen, Karl Emil ; Pagsberg, Anne Katrine ; Plessen, Kerstin Jessica ; Hansen, Poul Erik ; Werge, Thomas ; Dyrborg, J. ; Lauritzen, Maj Britt ; Hughes, Tim
in journal: Pharmacogenetics and Genomics (ISSN: 1744-6872) (DOI: http://dx.doi.org/10.1097/FPC.0000000000000255), vol: 27, issue: 2, pages: 78-80, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1097/FPC.0000000000000255

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CD49a Expression Defines Tissue-Resident CD8+ T Cells Poised for Cytotoxic Function in Human Skin

Cheuk, Stanley ; Schlums, Heinrich ; Sérézal, Irène Gallais ; Martini, Elisa ; Chiang, Samuel C. ; Marquardt, Nicole ; Gibbs, Anna ; Detlofsson, Ebba ; Introini, Andrea ; Forkel, Marianne ; Höög, Charlotte ; Tjernlund, Annelie ; Michaelsson, Jakob ; Folkersen, Lasse Westergaard ; Mjösberg, Jenny ; Blomqvist, Lennart ; Ehrström, Marcus ; Ståhle, Mona ; Bryceson, Yenan T. ; Eidsmo, Liv
in journal: Immunity (ISSN: 1074-7613) (DOI: http://dx.doi.org/10.1016/j.immuni.2017.01.009), vol: 46, issue: 2, pages: 287-300, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1016/j.immuni.2017.01.009

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Chromosome-wise Protein Interaction Patterns and Their Impact on Functional Implications of Large-Scale Genomic Aberrations

Kirk, Isa Kristina ; Weinhold, Nils ; Belling, Kirstine González-Izarzugaza ; Skakkebæk, Niels Erik ; Jensen, Thomas Skøt ; Leffers, Henrik ; Juul, Anders ; Brunak, Søren
in journal: Cell Systems (ISSN: 2405-4712) (DOI: http://dx.doi.org/10.1016/j.cels.2017.01.001), vol: 4, issue: 3, pages: 357-364, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1016/j.cels.2017.01.001

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Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease

Folkersen, Lasse Westergaard ; Fauman, Eric ; Sabater-Lleal, Maria ; Strawbridge, Rona J. ; Frånberg, Mattias ; Sennblad, Bengt ; Baldassarre, Damiano ; Veglia, Fabrizio ; Humphries, Steve E ; Rauramaa, Rainer ; de Faire, Ulf ; Smit, Andries J ; Giral, Philippe ; Kurl, Sudhir ; Mannarino, Elmo ; Enroth, Stefan ; Johansson, Åsa ; Enroth, Sofia Bosdotter ; Gustafsson, Stefan ; Lind, Lars ; Lindgren, Cecilia M. ; Morris, Andrew P ; Giedraitis, Vilmantas ; Silveira, Angela ; Franco-Cereceda, Anders ; Tremoli, Elena ; Gyllensten, Ulf ; Ingelsson, Erik ; Brunak, Søren ; Eriksson, Per ; Ziemek, Daniel ; Hamsten, Anders ; Mälarstig, Anders
in journal: P L o S Genetics (ISSN: 1553-7390) (DOI: http://dx.doi.org/10.1371/journal.pgen.1006706), 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1371/journal.pgen.1006706

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Pancreatic Islet Protein Complexes and Their Dysregulation in Type 2 Diabetes

Pedersen, Helle Krogh ; Gudmundsdottir, Valborg ; Brunak, Søren
in journal: Frontiers in Genetics (ISSN: 1664-8021) (DOI: http://dx.doi.org/10.3389/fgene.2017.00043), vol: 8, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.3389/fgene.2017.00043

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Functional Analysis of the Coronary Heart Disease Risk Locus on Chromosome 21q22

Beaney, Katherine E. ; Smith, Andrew J. P. ; Folkersen, Lasse Westergaard ; Palmen, Jutta ; Wannamethee, S. Goya ; Jefferis, Barbara J. ; Whincup, Peter ; Gaunt, Tom R. ; Casas, Juan P. ; Ben-Shlomo, Yoav ; Price, Jacqueline F. ; Kumari, Meena ; Wong, Andrew ; Ong, Ken ; Hardy, Rebecca ; Kuh, Diana ; Wareham, Nicholas ; Kivimaki, Mika ; Eriksson, Per ; Humphries, Steve E.
in journal: Disease Markers (ISSN: 0278-0240) (DOI: http://dx.doi.org/10.1155/2017/1096916), vol: 2017, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1155/2017/1096916

 

Characterisation of lactic acid bacteria in spontaneously fermented camel milk and selection of strains for fermentation of camel milk

Fugl, Angelina June Brandt ; Berhe, Tesfemariam ; Kiran, Anil ; Hussain, Shazad ; Laursen, Martin Frederik ; Bahl, Martin Iain ; Hailu, Yonas ; Sørensen, Kim Ib ; Guya, Mituku Eshetu ; Ipsen, Richard ; Hansen, Egon Bech
in journal: International Dairy Journal (ISSN: 0958-6946) (DOI: http://dx.doi.org/10.1016/j.idairyj.2017.04.007), vol: 73, pages: 19-24, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1016/j.idairyj.2017.04.007

 

Comparison of global gene expression profiles of microdissected human foetal Leydig cells with their normal and hyperplastic adult equivalents

Lottrup, Grete ; Belling, Kirstine González-Izarzugaza ; Leffers, Henrik ; Nielsen, John E. ; Dalgaard, Marlene Danner ; Juul, Anders ; Skakkebæk, Niels E. ; Brunak, Søren ; Rajpert-De Meyts, Ewa
in journal: Molecular Human Reproduction (ISSN: 1360-9947) (DOI: http://dx.doi.org/10.1093/molehr/gax012), vol: 23, issue: 5, pages: 339-354, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1093/molehr/gax012

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Lapatinib potentiates cytotoxicity of YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter

Radic-Sarikas, Branka ; Halasz, Melinda ; Huber, Kilian V. M. ; Winter, Georg E. ; Tsafou, Kalliopi P. ; Papamarkou, Theodore ; Brunak, Søren ; Kolch, Walter ; Superti-Furga, Giulio
in journal: Scientific Reports (ISSN: 2045-2322) (DOI: http://dx.doi.org/10.1038/s41598-017-03129-6), vol: 7, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1038/s41598-017-03129-6

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Protein-altering and regulatory genetic variants near GATA4 implicated in bicuspid aortic valve

Yang, Bo ; Zhou, Wei-Wu ; Jiao, Jiao ; Nielsen, Jonas B. ; Mathis, Michael R. ; Heydarpour, Mahyar ; Lettre, Guillaume ; Folkersen, Lasse Westergaard ; Prakash, Siddharth ; Schurmann, Claudia ; Fritsche, Lars ; Farnum, Gregory A. ; Lin, Maoxuan ; Othman, Mohammad ; Hornsby, Whitney ; Driscoll, Anisa ; Levasseur, Alexandra ; Thomas, Marc ; Farhat, Linda ; Dube, Marie-Pierre ; Isselbacher, Eric M. ; Franco-Cereceda, Anders ; Guo, Dong-Chuan ; Bottinger, Erwin P. ; Deeb, G. Michael ; Booher, Anna ; Kheterpal, Sachin ; Chen, Y. Eugene ; Kang, Hyun Min ; Kitzman, Jacob ; Cordell, Heather J. ; Keavney, Bernard D. ; Goodship, Judith A. ; Ganesh, Santhi K. ; Abecasis, Goncalo ; Eagle, Kim A. ; Boyle, Alan P. ; Loos, Ruth J. F. ; Eriksson, Per ; Tardif, Jean-Claude ; Brummett, Chad M. ; Milewicz, Dianna M. ; Body, Simon C. ; Willer, Cristen J.
in journal: Nature Communications (ISSN: 2041-1723) (DOI: http://dx.doi.org/10.1038/ncomms15481), vol: 8, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1038/ncomms15481

 

Protein features as determinants of wild-type glycoside hydrolase thermostability

Geertz-Hansen, Henrik Marcus ; Kiemer, Lars ; Nielsen, Morten ; Stanchev, Kiril ; Blom, Nikolaj ; Brunak, Søren ; Petersen, Thomas Nordahl
in journal: Proteins (ISSN: 0887-3585) (DOI: http://dx.doi.org/10.1002/prot.25357), vol: 85, issue: 11, pages: 2036-2044, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1002/prot.25357

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Sequencing and de novo assembly of 150 genomes from Denmark as a population reference

Maretty, Lasse ; Jensen, Jacob Malte ; Petersen, Bent ; Sibbesen, Jonas Andreas ; Liu, Siyang ; Villesen, Palle ; Skov, Laurits ; Belling, Kirstine González-Izarzugaza ; Theil Have, Christian ; Gonzalez-Izarzugaza, Jose Maria ; Grosjean, Marie ; Bork-Jensen, Jette ; Grove, Jakob ; Als, Thomas D. ; Huang, Shujia ; Chang, Yuqi ; Xu, Ruiqi ; Ye, Weijian ; Rao, Junhua ; Guo, Xiaosen ; Sun, Jihua ; Cao, Hongzhi ; Ye, Chen ; van Beusekom, Johan ; Espeseth, Thomas ; Flindt, Esben N. ; Friborg, Rune M. ; Halager, Anders E. ; Le Hellard, Stephanie ; Hultman, Christina M. ; Lescai, Francesco ; Li, Shengting ; Lund, Ole ; Løngreen, Peter ; Mailund, Thomas ; Matey-Hernandez, María Luisa ; Mors, Ole ; Pedersen, Christian N. S. ; Sicheritz-Pontén, Thomas ; Sullivan, Patrick F. ; Syed, Ali ; Westergaard, David ; Yadav, Rachita ; Li, Ning ; Xu, Xun ; Hansen, Torben ; Krogh, Anders ; Bolund, Lars ; Sørensen, Thorkild I. A. ; Pedersen, Oluf ; Gupta, Ramneek ; Rasmussen, Simon ; Besenbacher, Søren ; Börglum, Anders D. ; Wang, Jun ; Eiberg, Hans ; Kristiansen, Karsten ; Brunak, Søren ; Schierup, Mikkel Heide
in journal: Nature (ISSN: 0028-0836) (DOI: http://dx.doi.org/10.1038/nature23264), vol: 548, pages: 87-91, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1038/nature23264

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Cross-recognition of a pit viper (Crotalinae) polyspecific antivenom explored through high-density peptide microarray epitope mapping

Engmark, Mikael ; Lomonte, Bruno ; Gutiérrez, José María ; Laustsen, Andreas Hougaard ; De Masi, Federico ; Andersen, Mikael Rørdam ; Lund, Ole
in journal: P L o S Neglected Tropical Diseases (Print) (ISSN: 1935-2727) (DOI: http://dx.doi.org/10.1371/journal.pntd.0005768), vol: 11, issue: 7, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1371/journal.pntd.0005768

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Assembly and analysis of 100 full MHC haplotypes from the Danish population

Jensen, Jacob M. ; Villesen, Palle ; Friborg, Rune M. ; Mailund, Thomas ; Besenbacher, Søren ; Schierup, Mikkel H. ; Gonzalez-Izarzugaza, Jose Maria
in journal: Genome Research (ISSN: 1088-9051) (DOI: http://dx.doi.org/10.1101/gr.218891.116), 2017

Type: Journal article (Peer reviewed)

Status: Accepted/In press     |    Year: 2017     |    DOI: http://dx.doi.org/10.1101/gr.218891.116

 

Identifying low density lipoprotein cholesterol associated variants in the Annexin A2 (ANXA2) gene

Fairoozy, Roaa Hani ; Cooper, Jackie ; White, Jon ; Giambartolomei, Claudia ; Folkersen, Lasse Westergaard ; Wannamethee, S. Goya ; Jefferis, Barbara J. ; Whincup, Peter H. ; Ben-Shlomo, Yoav ; Kumari, Meena ; Kivimaki, Mika ; Wong, Andrew ; Hardy, Rebecca ; Kuh, Diana ; Gaunt, Tom R. ; Casas, Juan P. ; McLachlan, Stela ; Price, Jackie F. ; Hingorani, Aroon D ; Franco-Cereceda, Anders ; Grewal, Thomas ; Kalea, Anastasia Z. ; Humphries, Steve E
in journal: Atherosclerosis (ISSN: 0021-9150) (DOI: http://dx.doi.org/10.1016/j.atherosclerosis.2017.04.010), vol: 261, pages: 60-68, 2017

Type: Journal article (Peer reviewed)

Status: Published     |    Year: 2017     |    DOI: http://dx.doi.org/10.1016/j.atherosclerosis.2017.04.010


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22 JANUARY 2018